Xavier T. Reveles Publications



Xavier T. Reveles Publications

Molecular cytogenetics as a clinical test for prognostic and predictive biomarkers in newly diagnosed ovarian cancer.

Gunn S, Reveles X, Weldon K, Barrera A, Ishaque M, Taylor D, McCaskill C, Kim J, Shah R, Mohammed M, Barry T, Kaiser B, Patnaik A, Tolcher A.

J Ovarian Res. 2013 Jan 4;6(1):2. doi: 10.1186/1757-2215-6-2.


PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.

Deshpande AM, Akunowicz JD, Reveles XT, Patel BB, Saria EA, Gorlick RG, Naylor SL, Leach RJ, Hansen MF.

Oncogene. 2007 Mar 15;26(12):1714-22. Epub 2006 Sep 25.


Detection of recurrent copy number loss at Yp11.2 involving TSPY gene cluster in prostate cancer using array-based comparative genomic hybridization.

Vijayakumar S, Hall DC, Reveles XT, Troyer DA, Thompson IM, Garcia D, Xiang R, Leach RJ, Johnson-Pais TL, Naylor SL.

Cancer Res. 2006 Apr 15;66(8):4055-64.


Use of DNA sequencing analysis to confirm fungemia due to Trichosporon dermatis in a pediatric patient.

Gunn SR, Reveles XT, Hamlington JD, Sadkowski LC, Johnson-Pais TL, Jorgensen JH.

J Clin Microbiol. 2006 Mar;44(3):1175-7.


Golli-MBP copy number analysis by FISH, QMPSF and MAPH in 195 patients with hypomyelinating leukodystrophies.

Vaurs-Barriere C, Bonnet-Dupeyron MN, Combes P, Gauthier-Barichard F, Reveles XT, Schiffmann R, Bertini E, Rodriguez D, Vago P, Armour JA, Saugier-Veber P, Frebourg T, Leach RJ, Boespflug-Tanguy O.

Ann Hum Genet. 2006 Jan;70(Pt 1):66-77.


Chromosome 18 suppresses prostate cancer metastases.

Padalecki SS, Weldon KS, Reveles XT, Buller CL, Grubbs B, Cui Y, Yin JJ, Hall DC, Hummer BT, Weissman BE, Dallas M, Guise TA, Leach RJ, Johnson-Pais TL.

Urol Oncol. 2003 Sep-Oct;21(5):366-73.


Molecular characterization of a patient with central nervous system dysmyelination and cryptic unbalanced translocation between chromosomes 4q and 18q.

Gunn SR, Mohammed M, Reveles XT, Viskochil DH, Palumbos JC, Johnson-Pais TL, Hale DE, Lancaster JL, Hardies LJ, Boespflug-Tanguy O, Cody JD, Leach RJ.

Am J Med Genet A. 2003 Jul 1;120A(1):127-35.


Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer.

Schneider BG, Rha SY, Chung HC, Bravo JC, Mera R, Torres JC, Plaisance KT Jr, Schlegel R, McBride CM, Reveles XT, Leach RJ.

Mol Pathol. 2003 Jun;56(3):141-9.


Molecular characterization of 18p deletions: evidence for a breakpoint cluster.

Schaub RL, Reveles XT, Baillargeon J, Leach RJ, Cody JD.

Genet Med. 2002 Jan-Feb;4(1):15-9.


Genetic mapping of a novel X-linked recessive colobomatous microphthalmia.

Lehman DM, Sponsel WE, Stratton RF, Mensah J, Macdonald JC, Johnson-Pais TL, Coon H, Reveles XT, Cody JD, Leach RJ.

Am J Med Genet. 2001 Jun 15;101(2):114-9.


Haplosufficiency of the melancortin-4 receptor gene in individuals with deletions of 18q.

Cody JD, Reveles XT, Hale DE, Lehman D, Coon H, Leach RJ.

Hum Genet. 1999 Nov;105(5):424-7.


Assignment of serine protease 17 (PRSS17) to human chromosome bands 19q13.3–>q13.4 by in situ hybridization.

DuPont BR, Hu CC, Reveles X, Simmer JP.

Cytogenet Cell Genet. 1999;86(3-4):212-3. No abstract available.



Porphyrin uptake in lung cancer cells by dynamin-mediated endocytosis: a novel marker of dysregulated endocytosis in cancer. American Society of Cell Biology Annual Meeting, December, 2015

Porphyrins are dynamic molecules involved in many biological processes, including oxygen and electron transport.  Porphyrins have also been known to incorporate more readily into cancer cells compared to non-cancerous cells, and this property of porphyrins is being explored for diagnostic and therapeutic applications in cancer patients.

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Early Detection of Lung Cancer with Meso Tetra (4-Carboxyphenyl) Porphine (TCPP)-Labeled Sputum, Journal of Thoracic Oncology, September, 2015

The clinical study demonstrated 81% accuracy in detecting cancer from sputum samples collected from participants in two cohorts. The high-risk cohort included military veterans who had smoked at least 20 pack-years.

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Internal Validation Research Trial

In this internal study, the assay revealed 100% specificity and 100% sensitivity.
Researchers investigated meso Tetra (4-Carboxyphenyl) Porphine (TCPP), a porphyrin that can label cancer cells.

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