Xavier T. Reveles Publications



Xavier T. Reveles Publications

Molecular cytogenetics as a clinical test for prognostic and predictive biomarkers in newly diagnosed ovarian cancer.

Gunn S, Reveles X, Weldon K, Barrera A, Ishaque M, Taylor D, McCaskill C, Kim J, Shah R, Mohammed M, Barry T, Kaiser B, Patnaik A, Tolcher A.

J Ovarian Res. 2013 Jan 4;6(1):2. doi: 10.1186/1757-2215-6-2.


PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.

Deshpande AM, Akunowicz JD, Reveles XT, Patel BB, Saria EA, Gorlick RG, Naylor SL, Leach RJ, Hansen MF.

Oncogene. 2007 Mar 15;26(12):1714-22. Epub 2006 Sep 25.


Detection of recurrent copy number loss at Yp11.2 involving TSPY gene cluster in prostate cancer using array-based comparative genomic hybridization.

Vijayakumar S, Hall DC, Reveles XT, Troyer DA, Thompson IM, Garcia D, Xiang R, Leach RJ, Johnson-Pais TL, Naylor SL.

Cancer Res. 2006 Apr 15;66(8):4055-64.


Use of DNA sequencing analysis to confirm fungemia due to Trichosporon dermatis in a pediatric patient.

Gunn SR, Reveles XT, Hamlington JD, Sadkowski LC, Johnson-Pais TL, Jorgensen JH.

J Clin Microbiol. 2006 Mar;44(3):1175-7.


Golli-MBP copy number analysis by FISH, QMPSF and MAPH in 195 patients with hypomyelinating leukodystrophies.

Vaurs-Barriere C, Bonnet-Dupeyron MN, Combes P, Gauthier-Barichard F, Reveles XT, Schiffmann R, Bertini E, Rodriguez D, Vago P, Armour JA, Saugier-Veber P, Frebourg T, Leach RJ, Boespflug-Tanguy O.

Ann Hum Genet. 2006 Jan;70(Pt 1):66-77.


Chromosome 18 suppresses prostate cancer metastases.

Padalecki SS, Weldon KS, Reveles XT, Buller CL, Grubbs B, Cui Y, Yin JJ, Hall DC, Hummer BT, Weissman BE, Dallas M, Guise TA, Leach RJ, Johnson-Pais TL.

Urol Oncol. 2003 Sep-Oct;21(5):366-73.


Molecular characterization of a patient with central nervous system dysmyelination and cryptic unbalanced translocation between chromosomes 4q and 18q.

Gunn SR, Mohammed M, Reveles XT, Viskochil DH, Palumbos JC, Johnson-Pais TL, Hale DE, Lancaster JL, Hardies LJ, Boespflug-Tanguy O, Cody JD, Leach RJ.

Am J Med Genet A. 2003 Jul 1;120A(1):127-35.


Regions of allelic imbalance in the distal portion of chromosome 12q in gastric cancer.

Schneider BG, Rha SY, Chung HC, Bravo JC, Mera R, Torres JC, Plaisance KT Jr, Schlegel R, McBride CM, Reveles XT, Leach RJ.

Mol Pathol. 2003 Jun;56(3):141-9.


Molecular characterization of 18p deletions: evidence for a breakpoint cluster.

Schaub RL, Reveles XT, Baillargeon J, Leach RJ, Cody JD.

Genet Med. 2002 Jan-Feb;4(1):15-9.


Genetic mapping of a novel X-linked recessive colobomatous microphthalmia.

Lehman DM, Sponsel WE, Stratton RF, Mensah J, Macdonald JC, Johnson-Pais TL, Coon H, Reveles XT, Cody JD, Leach RJ.

Am J Med Genet. 2001 Jun 15;101(2):114-9.


Haplosufficiency of the melancortin-4 receptor gene in individuals with deletions of 18q.

Cody JD, Reveles XT, Hale DE, Lehman D, Coon H, Leach RJ.

Hum Genet. 1999 Nov;105(5):424-7.


Assignment of serine protease 17 (PRSS17) to human chromosome bands 19q13.3–>q13.4 by in situ hybridization.

DuPont BR, Hu CC, Reveles X, Simmer JP.

Cytogenet Cell Genet. 1999;86(3-4):212-3. No abstract available.



Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells, Journal of the Federation of Societies for the Study of Experimental Biology (FASEB Journal), Feb. 25, 2021

The paper explains research that identified a novel mechanism by which the porphyrin TCPP, which is used in bioAffinity Technologies’ non-invasive test for the early detection of lung cancer, is incorporated into cancer cells using the cellular receptor CD320, which is involved in the uptake of Vitamin B12.

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Automated Flow Cytometry Test Distinguishes Cancer from Non-Cancer in Sputum with High Sensitivity and Specificity, International Association for the Study of Lung Cancer (IASLC) 2020 World Conference on Lung Cancer, Jan. 2021

The automated CyPath® Lung flow cytometric assay correctly classifies study participants into cancer or high risk cohorts with high accuracy, including participants with nodules smaller than 20 mm. The CyPath® Lung assay thus has the potential to complement LDCT screening and improve diagnosis of early stage lung cancer.

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Meso-tetra (4-carboxyphenyl) porphyrin (TCPP) is incorporated into cancer cells by the CD320 receptor and clathrin mediated endocytosis, Poster Presentation, American Society of Cell Biology’s Cell Bio Virtual 2020; Cancer Therapy: Defining Therapeutic Targets and New Therapeutics, December 2-16, 2020.

Porphyrins have been used successfully to treat and diagnose cancer, yet the mechanism of how porphyrins are selectively taken up and how they are retained by cancer cells compared to other cells remains poorly understood. Knowledge about the cellular uptake and retention mechanisms of porphyrins can be used to design more effective porphyrin-based diagnostics and therapeutics.

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