Scientific Publications

Innovative scientific research aimed at developing non-invasive diagnostics and broad-spectrum therapeutics in the fight against cancer

Peer-Reviewed Papers & Conference Presentations

Scientific Papers

Porphyrin-Modified Beads for Use as Compensation Controls in Flow Cytometry

JoVE Journal, March 24, 2023 Authors William Bauta, Marcia Grayson, Rossella Titone, Jennifer Rebeles, Vivienne I. Rebel Abstract Flow cytometry can rapidly characterize and quantify diverse cell populations based on fluorescence measurements. The cells are first stained with one or more fluorescent reagents, each functionalized with a different fluorescent molecule (fluorophore) that binds to cells selectively based on their phenotypic characteristics, such as cell surface antigen expression. The intensity of fluorescence from each reagent bound to cells can be measured on the flow cytometer using channels that detect a specified range of wavelengths. When multiple fluorophores are used, the light from individual fluorophores often spills over into undesired detection channels, which requires a correction to the fluorescence intensity data...
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Reassessing Cobalamin Requirements in Cell Culture

Cell Bio, a joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), in Washington, D.C., on Dec. 3-7, 2022. AuthorsDavid J. Elzi, Reggie Jacob, and Vivienne I. Rebel Introduction Cobalamin (Vitamin B12) is an essential co-factor for the synthesis of components required...

Quality-Controlled Sputum Analysis by Flow Cytometry

Journal of Visualized Experiments (JoVE) – August 9, 2021 AuthorsMarcia Grayson, Shao-Chiang Lai, Lydia H. Bederka, Patricia Araujo, Jamila Sanchez, Xavier T. Reveles, Vivienne I. Rebel, Jennifer Rebeles AbstractSputum, widely used to study the cellular content and other microenvironmental features to understand the health of the lung, is traditionally...

Selective Cancer Cell Killing by Dual siRNA Knockdown of CD320 and LRP2 Receptors

“Selective Cancer Cell Killing by Dual siRNA Knockdown of CD320 and LRP2 Receptors” RNA Therapeutics Institute’s 2021 RNA Therapeutics Symposium at the University of Massachusetts Medical School June 23 – 25, 2021   Authors David J. Elzi, William E. Bauta, Shao-Chiang Lai, Trisha Das, Shweta Mogare, and Vivienne I....

Meso-tetra (4-carboxyphenyl) porphyrin (TCPP) is incorporated into cancer cells by the CD320 receptor and clathrin mediated endocytosis

“Meso-tetra (4-carboxyphenyl) porphyrin (TCPP) is incorporated into cancer cells by the CD320 receptor and clathrin-mediated endocytosis, Poster Presentation" American Society of Cell Biology’s Cell Bio Virtual 2020; Cancer Therapy: Defining Therapeutic Targets and New Therapeutics, December 2-16, 2020   Authors D. J. Elzi, W. E. Bauta, J. R. Sanchez,...

Sputum-Derived Cellular Profiles Produced by Flow Cytometric Analysis

"Sputum-Derived Cellular Profiles Produced by Flow Cytometric Analysis, Poster" International Society for Advancement of Cytometry CYTO 2020, August 4-5, 2020   Authors Lydia H. Bederka, Shao-Chiang Lai, Jennifer Rebeles, Marcia H. Grayson, Xavier T. Reveles, and Vivienne I. Rebel   Abstract Sputum consists of a complex mixture of mucus...

Internal Validation Research Trial

Internal Validation Research Trial February 1, 2015 27 sputum samples: 15 lung cancer sputum samples and 12 sputum samples from patients without lung cancer, December, 2008 AuthorsT. Bauer II, MD, Helen F. Graham Cancer Center; D. Merrick, MD, Denver VA Medical Center; T. C. Kennedy, MD, University of Colorado...

Research at Los Alamos National Laboratory and St Mary’s Hospital

Research at Los Alamos National Laboratory and St Mary’s Hospital January 15, 2015 St. Mary’s Hospital and the Isotope and Nuclear Chemistry Division of the Medical Radioisotopes Research Program at Los Alamos National Laboratory conducted preliminary studies from 1988 to 1992 researching porphyrins that led to more specific research...
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The CyPath® Lung Flow Cytometry Test is sold by Precision Pathology Laboratory Services, a bioAffinity Technologies company,  as a Laboratory Developed Test (LDT).

CyPath® Lung is a non-invasive test that assists clinical decision-making in lung cancer patients whose low-dose computed tomography (LDCT) has demonstrated a suspicious finding.

The test reveals the lung micro-environment by automated analysis of sputum using flow cytometry to characterize cell populations indicative of cancer in the lung.

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