Clinical Trials and Research Studies

Meso-tetra (4-carboxyphenyl) porphyrin (TCPP) is incorporated into cancer cells by the CD320 receptor and clathrin mediated endocytosis, Poster Presentation, American Society of Cell Biology’s Cell Bio Virtual 2020; Cancer Therapy: Defining Therapeutic Targets and New Therapeutics, December 2-16, 2020.

Porphyrins have been used successfully to treat and diagnose cancer, yet the mechanism of how porphyrins are selectively taken up and how they are retained by cancer cells compared to other cells remains poorly understood. Knowledge about the cellular uptake and retention mechanisms of porphyrins can be used to design more effective porphyrin-based diagnostics and therapeutics.

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Sputum-Derived Cellular Profiles Produced by Flow Cytometric Analysis. Poster, International Society for Advancement of Cytometry CYTO 2020, August 4-5, 2020

Sputum consists of a complex mixture of mucus from the lungs and a variety of cell types including cancer cells if a tumor is present.  Sputum can be collected non-invasively with no patient side-effects which makes it an ideal specimen for diagnostic purposes.  Sputum cytology was for decades the only tool available to diagnose lung cancer.

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Porphyrin uptake in lung cancer cells by dynamin-mediated endocytosis: a novel marker of dysregulated endocytosis in cancer. American Society of Cell Biology Annual Meeting, December, 2015

Porphyrins are dynamic molecules involved in many biological processes, including oxygen and electron transport.  Porphyrins have also been known to incorporate more readily into cancer cells compared to non-cancerous cells, and this property of porphyrins is being explored for diagnostic and therapeutic applications in cancer patients.

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