Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells, Journal of the Federation of Societies for the Study of Experimental Biology (FASEB Journal), Feb. 25, 2021

PUBLISHED ON April 20, 2021

The paper explains research that identified a novel mechanism by which the porphyrin TCPP, which is used in bioAffinity Technologies’ non-invasive test for the early detection of lung cancer, is incorporated into cancer cells using the cellular receptor CD320, which is involved in the uptake of Vitamin B12.

Automated Flow Cytometry Test Distinguishes Cancer from Non-Cancer in Sputum with High Sensitivity and Specificity, International Association for the Study of Lung Cancer (IASLC) 2020 World Conference on Lung Cancer, Jan. 2021

PUBLISHED ON February 5, 2021

The automated CyPath^® Lung flow cytometric assay correctly classifies study participants into cancer or high risk cohorts with high accuracy, including participants with nodules smaller than 20 mm. The CyPath^® Lung assay thus has the potential to complement LDCT screening and improve diagnosis of early stage lung cancer.

Meso-tetra (4-carboxyphenyl) porphyrin (TCPP) is incorporated into cancer cells by the CD320 receptor and clathrin mediated endocytosis, Poster Presentation, American Society of Cell Biology’s Cell Bio Virtual 2020; Cancer Therapy: Defining Therapeutic Targets and New Therapeutics, December 2-16, 2020.

PUBLISHED ON December 28, 2020

Porphyrins have been used successfully to treat and diagnose cancer, yet the mechanism of how porphyrins are selectively taken up and how they are retained by cancer cells compared to other cells remains poorly understood. Knowledge about the cellular uptake and retention mechanisms of porphyrins can be used to design more effective porphyrin-based diagnostics and therapeutics.

Sputum-Derived Cellular Profiles Produced by Flow Cytometric Analysis. Poster, International Society for Advancement of Cytometry CYTO 2020, August 4-5, 2020

PUBLISHED ON July 27, 2020

Sputum consists of a complex mixture of mucus from the lungs and a variety of cell types including cancer cells if a tumor is present. Sputum can be collected non-invasively with no patient side-effects which makes it an ideal specimen for diagnostic purposes. Sputum cytology was for decades the only tool available to diagnose lung cancer.

Porphyrin uptake in lung cancer cells by dynamin-mediated endocytosis: a novel marker of dysregulated endocytosis in cancer. American Society of Cell Biology Annual Meeting, December, 2015

PUBLISHED ON December 25, 2015

Porphyrins are dynamic molecules involved in many biological processes, including oxygen and electron transport. Porphyrins have also been known to incorporate more readily into cancer cells compared to non-cancerous cells, and this property of porphyrins is being explored for diagnostic and therapeutic applications in cancer patients.